关键词: 支气管闭塞, 闭塞性支气管炎, 闭塞性细支气管炎, 临床特征

Abstract: Objective 　To analyze the clinical characteristics of bronchitis obliterans in children， and to discuss the differences between its clinical characteristics and those of bronchiolitis obliterans， so as to achieve early recognition and treatment of bronchitis obliterans. Methods　The clinical data of those children who were diagnosed with bronchitis obliterans and bronchiolitis obliterans in Children's Hospital Affiliated to Chongqing Medical University from January 2021 to December 2021 were collected. The patients were divided into simple bronchitis obliterans group ， simple bronchiolitis obliterans group and bronchiolitis obliterans combined with bronchiolitis obliterans group （referred to as combination group）. The clinical characteristics， laboratory examination， imaging examination results and treatment were compared. Results　The onset age of simple bronchitis obliterans group  was higher than that of the other two groups. The symptoms of wheezing， repeated wheezing， shortness of breath， activity intolerance， dyspnea and three concave signs in simple bronchiolitis obliterans group were significantly more obvious than those in simple bronchitis obliterans group ; the symptoms of wheezing， repeated wheezing， shortness of breath and activity intolerance in combination group were more obvious than those in simple bronchitis obliterans group ; the reduction of breath sound in simple bronchitis obliterans group  was more obvious than that in simple bronchiolitis obliterans group; The total number of cells， nuclei， neutrophils， lymphocytes， phagocytes and pleural effusion in alveolar lavage fluid of simple bronchitis obliterans group  were more than those of simple bronchiolitis obliterans group; the number of lymphocytes in lavage fluid of simple bronchitis obliterans group  was more than that of combination group; the degree of pulmonary dysfunction of simple bronchitis obliterans group  was less severe than that of the other two groups， and the use of invasive ventilator was less than that of the other two groups. Conclusion　The clinical manifestations of children with bronchitis obliterans are similar to those of bronchiolitis obliterans， but the manifestations of bronchitis obliterans are generally less severe than those of bronchiolitis obliterans， and the degree of pulmonary dysfunction is also less severe. Bronchoscopy and the total number of cells and neutrophils in alveolar lavage fluid may be clues for identification. Bronchoscopic lavage therapy and targeted and aggressive anti-infective therapy may be helpful in preventing further development of bronchial occlusion in these patients.

Key words: occlusion of bronchus, bronchitis obliterans, bronchiolitis obliterans, clinical characteristics