中国实用儿科杂志

中国实用儿科杂志

• 专题笔谈 • 上一篇    下一篇

儿童癫痫共患孤独症

  

  1. 北京大学精神卫生研究所，北京大学第六医院，卫生部精神卫生学重点实验室，国家精神心理疾病临床医学研究中心（北京大学），北京  100191
  • 出版日期:2017-04-06 发布日期:2017-03-31

Child epilepsy comorbid with autism

  1. Peking University Institute of Mental Health，Peking University Sixth Hospital，Key Laboratory of Mental Health，Ministry of Health，National Clinical Research Center for Mental Disorder（Peking University），Beijing  100191，China
  • Online:2017-04-06 Published:2017-03-31

摘要：

癫痫和孤独症共患是较为常见的临床现象，5%～37%的癫痫儿童共患孤独症（或孤独症筛查阳性），2%～46%的孤独症或孤独症谱系障碍患者共患癫痫。精神疾病家族史、围生期不利因素、女性、孤独症特征、智力障碍、遗传或神经综合征、遗传因素等增加两种疾病共患风险。两种疾病共患时，癫痫起病更早，存在学龄前和青春期两个起病高峰，部分性发作更多见，难治性发生率更高，孤独症症状更严重，智力障碍更突出，运动发育问题和行为症状更多见，适应不良更明显。及时识别、正确诊断和规范治疗两种疾病非常重要。

关键词: 癫痫, 孤独症, 共患病, 儿童

Abstract:

The comorbidity of epilepsy and autism is a common clinical phenomenon. About 5%～37% of children with epilepsy have autism or have positive screening for autism. About 2%～46% of individuals with autism have epilepsy. The family history of mental disorders，adverse perinatal factors，female，autistic features，intelligence disability，genetic or neurological syndromes and genetic factors increase the risk of comorbidity of the two diseases. In children with the two diseases，epilepsy onsets earlier with two onset peaks before 5 years and during puberty；partial seizure and intractable epilepsy is more common；the symptom of autism is more severe，with more intelligence disability，more motor development and behavior problems and worse adaption behaviors. It is important to recognize， diagnose and treat the two diseases.

Key words: epilepsy, autism, comorbidity, child