Abstract:

Alzheimer's disease is the most common form of dementia associated with environmental factors. Periodontitis is a chronic infectious disease that occurs in periodontal supporting tissues. Studies have found a close association between periodontitis and Alzheimer′s disease，but the potential mechanism linking periodontitis with Alzheimer′s disease is not fully clear. It might be that the inflammatory response and vascular changes are the two mediators of the disease，and the common risk factors promote the development of both diseases. The recent findings of the association between periodontitis and Alzheimer′s disease were discussed in this paper.

Key words: periodontitis；Alzheimer&prime, s disease；periodontal pathogen；inflammatory response；risk factor

摘要：

阿尔兹海默症是一种最常见的老年痴呆症，与环境因素密切相关。牙周炎是发生在牙周支持组织的一种慢性感染性疾病。研究表明，牙周炎与阿尔兹海默症的发生发展密切相关，但作用机制尚未完全明确，炎症反应及血管结构的改变可能是两种疾病的中介，共同的危险因素促进两种疾病的发生发展。文章就近年来牙周炎与阿尔兹海默症相关性的研究进展做一综述。

关键词: 牙周炎, 阿尔兹海默症, 牙周致病菌, 炎症反应, 危险因素