Abstract:

Porphyromonas gingivalis， a gram-negative obligate anaerobic bacterium，has been proved to be one of the main periodontal pathogens， participating in development of periodontitis and process of periodontal tissue destruction. Previous studies have demonstrated the close relationship between periodontal infection and systemic health and diseases. P. gingivalis infection on host cells mediated cell apoptosis by interfering with cell signal transduction and expression of related proteins. This article reviews research progress of P. gingivalis infection on mediation of apoptosis of host cells.

Key words: Porphyromonas gingivalis, host cells, cell apoptosis, mediate

摘要：

牙龈卟啉单胞菌（Porphyromonas gingivalis）是证据充分的重要的牙周致病菌之一，参与牙周炎的发生、发展及牙周组织的破坏过程。以往研究表明，牙周感染与全身健康及系统疾病均有着密切关系。P. gingivalis感染多种宿主细胞后，通过干扰相关信号传导及蛋白表达，对宿主细胞凋亡进行调控。现就P. gingivalis感染宿主细胞后对其凋亡调控研究进展做一综述。

关键词: 牙龈卟啉单胞菌, 宿主细胞, 细胞凋亡, 调控