Research advances in the interactions between dental tissue-derived stem cells and inflammation.

doi:10.7504/kq.2015.01.014

Abstract

Abstract:

Abstract：Dental tissue-derived stem cells have self-renewal，multipotential differentiation and immunomodulatory properties. Recent researches revealed that they play an important role in tissue regeneration，cell therapy of autoimmune and inflammation-ralated diseases. They have been found to interact closely with inflammation. On one hand，immune cells and pro-inflammatory cytikines can affect proliferation and differentiation of dental tissue-derived stem cells. On the other hand，dental tissue-derived stem cells have the ability to modulate immune and inflammation response via soluble factors and cell-cell contact. In this review，we discuss current studies on the immunomodulatory properties of dental tissue-derived stem cells and the effects of inflammation on dental tissue-derived stem cells.

Key words: dental tissue-derived stem cells, inflammation, proliferation, differentiation, immunomodulation

摘要：

牙源性干细胞具有自我更新、多向分化和免疫调节的潜能。近年来研究表明，牙源性干细胞在组织再生、免疫和炎症相关疾病的治疗方面发挥了重要作用。牙源性干细胞与炎症之间存在着一定的相互作用：一方面，炎症状态下免疫细胞和细胞因子影响牙源性干细胞的增殖分化能力；另一方面，牙源性干细胞能够调节免疫和炎症应答。本文对牙源性干细胞与炎症相互作用的研究进展做一综述。

关键词: 牙源性干细胞, 炎症, 增殖, 分化, 免疫调节

CLC Number:

Ｒ78

LIU Xue-mei，LIU Yao，CHEN Xu. Research advances in the interactions between dental tissue-derived stem cells and inflammation.[J]. Acta Metallurgica Sinica, DOI: 10.7504/kq.2015.01.014.

刘雪梅，刘尧综述，陈旭审校. 牙源性干细胞与炎症相互作用研究进展[J]. 中国实用口腔科杂志, DOI: 10.7504/kq.2015.01.014.

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