Abstract:

Abstract：Objective To evaluate the treatment effect of initial periodontal therapy on drug-induced gingival overgrowth by phenytoin. Methods Sixteen cases of gingival overgrowth induced by phenytoin from January 2011 to June 2013 in Chancheng District Xiangyang Hospital of Foshan & Chancheng Stomatological Hospital were selected in this clinical study. Initial periodontal therapy was done without changing to other drugs or withdrawing of phenytoin. The gingival hyperplastic index（GHI），plaque index（PLI），sulcus bleeding index（SBI）and probing depth（PD）were scored on labial sites of the anterior teeth. After initial periodontal therapy，the above indices were examined again at 1 month，3 months and 6 months. Results After 1，3 and 6 months，GHI，PLI，SBI and PD index improved gradually，gingival inflammation reduced gradually，and condition of gingival hyperplasia improved continuously；compared with the baseline before treatment，the differences had statistical significance（P < 0.05）. Conclusion Initial periodontal therapy is effective in reducing drug-induced gingival overgrowth by phenytoin.

Key words: phenytoin, gingival overgrowth, initial periodental therapy

摘要：

目的 评价单纯牙周基础治疗对苯妥英钠（PHT）所致药物性牙龈增生的治疗效果。方法 选择佛山市禅城区向阳医院·禅城区口腔医院2011年1月至2013年6月因服用PHT导致牙龈增生的患者16例，在不停药亦不换药的情况下行牙周基础治疗，并于治疗前及治疗后1、3、6个月进行牙龈增生指数（GHI）、菌斑指数（PLI）、龈沟出血指数（SBI）、探诊深度（PD）等临床指标检查。结果 单纯牙周基础治疗后1、3、6个月的GHI、PLI、SBI、PD各项临床指标逐步改善，牙龈炎症逐步减轻，牙龈增生状况持续好转；与治疗前基线相比，差异均有统计学意义（均P < 0.05）。结论 单纯牙周基础治疗对PHT所致药物性牙龈增生有效。

关键词: 苯妥英钠, 牙龈增生, 牙周基础治疗