Abstract: Objective    To evaluate the clinical effect of concentrated growth factors（CGF）combined with minimally invasive surgical technique（MIST）in the treatment of vertical bone defects in periodontitis. Methods    A total of 39 patients with vertical bone defect of periodontitis who were treated in the Periodontology Department of Hefei Stomatological Hospital from September 2020 to July 2021 were selected and randomly divided into 3 groups with 13 cases in each group. The three groups were treated with periodontal guided tissue regeneration（GTR）（GTR group），GTR combined with CGF （GTR+CGF group），and MIST（head-mounted magnifying glass + gingival-preserving papilla incision + thin needle fine thread and modified mattress suture） combined with CGF （MIST+ CGF group），respectively. The probing depth（PD），bleeding index （BI），clinical attachment loss（CAL），depth of alveolar bone defect，and depth of gingival recession at the vertical bone defect site were compared before and 6 months after surgery in the three groups. Results    There was no significant difference in the measurement indicators among the three groups before operation（all P > 0.05）；6 months after the operation，the PD，BI，CAL and depth of alveolar bone defect in the three groups were all significantly improved compared with those before operation；gingival recession occurred in all three groups，and the difference was statistically significant（all P < 0.05）. At 6 months after operation，there was no significant difference in the measurement indicators among the three groups（all P > 0.05）. Conclusion    CGF combined with MIST in the treatment of vertical bone defects in periodontitis has the same clinical effect as traditional treatment methods，and its advantages need to be further studied.

Key words: concentrated growth factors, minimally invasive surgical technique, gingival recession, periodontal tissue regeneration

摘要： 目的    评价浓缩生长因子（concentrated growth factors，CGF）联合微创外科技术（minimally invasive surgical technique，MIST）治疗牙周炎垂直骨缺损的临床效果。方法    选取2020年9月至2021年7月于合肥市口腔医院牙周科就诊的牙周炎垂直骨缺损患者39例，随机分为3组，每组各13例，分别采用牙周引导组织再生术（guided tissue regeneration，GTR）（GTR组）、GTR联合CGF（GTR+CGF组）、MIST（头戴式放大镜+保留龈乳头切口+细针细线改良褥式缝合）联合CGF（MIST+CGF组）进行治疗。比较3组患者术前、术后6个月垂直骨缺损位点的探诊深度（probing depth，PD）、出血指数（bleeding index，BI）、临床附着丧失（clinical attachment loss，CAL）、牙槽骨缺损深度和牙龈退缩深度。结果    3组术前各项测量指标比较，差异均无统计学意义（均P > 0.05）；术后6个月，3组PD、BI、CAL和牙槽骨缺损深度相较于术前均有明显改善，但也均发生了牙龈退缩，差异均有统计学意义（均P < 0.05）；术后6个月，3组各项测量指标比较，差异均无统计学意义（均P > 0.05）。结论    CGF联合MIST治疗牙周炎垂直骨缺损与传统治疗方法一样具有良好的临床效果，其优势有待进一步研究。

关键词: 浓缩生长因子, 微创外科技术, 牙龈退缩, 牙周组织再生