Abstract: Inflammation，trauma，tumors，congenital malformations，and periodontitis can cause oral bone tissue loss. Bone grafting or increasing bone mass are currently the main methods for repairing oral bone defects. The ideal bone repair material should have good biocompatibility，osteoinduction，osteoconductivity and osteogenic properties. Autogenous bones have limited sources，and allogeneic bones have problems such as immune rejection，cross-infection of diseases，etc. Therefore，the development of ideal bone repair materials is currently a research focus in the field of stomatology field. Nano-hydroxyapatite / collagen composites （nHAC）are prepared through in vitro biomimetic mineralization process，and have the same chemical composition and layered structure as natural bone tissue，being with good biocompatibility，osteoconductivity，osteoinduction and biodegradation，so they are widely studied and used. In this paper，the composition，properties，clinical application and research progress of nHAC are reviewed through analysis of relevant literatures，which lays a foundation for its clinical application.

Key words: Nano-hydroxyapatite/collagen composite, nHAC；bone defect；biomimetic mineralization；biodegradability

摘要： 炎症、外伤、肿瘤、先天性畸形以及牙周炎等均可导致口腔骨缺损，植骨或增加骨量是目前口腔骨缺损修复的主要方式。理想的骨修复材料应具有良好的生物相容性、骨诱导性、骨传导性和成骨特性。由于自体骨来源有限，同种异体骨存在免疫排斥反应、疾病交叉感染等问题，因此研发理想的骨修复材料是目前口腔领域的研究热点。纳米羟基磷灰石/胶原复合材料（nano-hydroxyapatite/collagen composite，nHAC）通过体外仿生矿化过程制备，与天然骨组织有相同的化学成分和分层结构，具有良好的生物相容性、骨传导性、骨诱导性和生物降解性等，因而被广泛研究与应用。文章通过检索分析相关文献对nHAC的组成、性能及其临床应用与研究进展做一综述，为其在临床中应用奠定基础。

关键词: 纳米羟基磷灰石/胶原复合材料, 骨缺损, 仿生矿化, 生物降解性