Abstract:

 Sjögren syndrome（SS）is classified as primary Sjögren syndrome（pSS）and secondary Sjögren syndrome（sSS）. It is an autoimmune exocrinopathy characterised by lymphocytic infiltration of exocrine glands in multiple sites，including both lacrimal and salivary glands，so the patients often suffer from dry mouth and dry eyes. Now the pathogeny and its pathogenesis is still  under study，and this review will elaborate from the aspects of cytokines，antibody，gene，virus and so on.

Key words: Sjögren syndrome, SS； pathogenesis； progress

摘要：

舍格伦综合征（SS）又称干燥综合征，分为原发性SS（pSS）和继发性SS（sSS），病变限于外分泌腺本身者称为pSS；伴发于其他自身免疫性疾病者称为sSS。现多认为SS是一种慢性自身免疫紊乱病，典型特征是唾液腺、泪腺的多发淋巴细胞浸润，主要表现为口干症和干眼症。尚有其他外分泌腺及腺体外其他器官的受累而出现多系统损害的症状。有关SS的病因及相应发病机制尚未明确，文章将从细胞因子、抗体、遗传因素等方面进行阐述。

关键词: 舍格伦综合征, 发病机制, 进展