Abstract:

Pain is an unpleasant subjective feeling and emotional experience related to tissue damage or potential tissue injury. So far， the etiology and pathogenesis of orofacial pain is not totally clear，which included temoporomandibular joint pain and migraine. Many cytokines play roles in pain. Transient receptor potential ion channel protein is a class of non-selective cation channel protein superfamily. Recent studies have indicated that transient receptor potential ankyrin1 （TRPA1） is closely related to pain. This was a review of the study on TAPA1 involved in orofacial pain.

Key words: pain, transient receptor potential ankyrin1（TRPA1）

摘要：

疼痛是一种与组织损伤或潜在组织损伤相关的不愉快的主观感觉和情感体验。目前，包括颞下颌关节疼痛及偏头痛在内的口颌面疼痛的发病机制尚未完全清楚。在疼痛过程中发挥作用的细胞因子较多，瞬时感受器电位离子通道蛋白 （ transient receptor potential ion channel protein， TRPs）是一类非选择性阳离子通道蛋白家族，近年研究发现，该蛋白家族亚族TRPA中的成员TRPA1与痛觉的产生关系密切。现就TRPA1及其参与口颌面疼痛的研究进展做一综述。

关键词: 疼痛, 瞬时感受器电位离子通道蛋白A1