中国实用口腔科杂志

中国实用口腔科杂志

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曲安奈德口腔软膏联合半导体激光治疗牙龈扁平苔藓临床疗效研究

董丽，麻嘉，张英   

  1. 中国医科大学附属口腔医院急诊·黏膜科，辽宁  沈阳  110002
  • 出版日期:2019-03-15 发布日期:2019-05-31
  • 基金资助:

    辽宁省教育厅课题（LFWK201716）

  • Online:2019-03-15 Published:2019-05-31

摘要：

目的　探讨曲安奈德口腔软膏联合半导体激光治疗牙龈扁平苔藓（lichen planus，LP）的临床疗效。方法　选取2016年9月至2017年10月就诊于中国医科大学附属口腔医院急诊·黏膜科至少由2名临床医生做出相同诊断的牙龈LP患者90例，随机分为A、B、C 3组，每组30例。A组患者采用曲安奈德口腔软膏治疗，每日1次，睡前涂抹，持续1个月； B组患者采用半导体激光局部照射治疗，每2日1次，持续1个月；C组患者采用曲安奈德口腔软膏联合半导体激光治疗，半导体激光先照射（每2日1次），然后药膏睡前涂抹（每日1次），疗程为1个月。分别在治疗前和治疗后1周、2周、1个月观察记录各组患者创面的病损面积、疼痛程度、症状体征。采用SPSS 22.0软件对数据进行统计分析。结果　治疗后3组病损面积均缩小，疼痛程度、症状体征评分均降低，较治疗前差异均有统计学意义（P＜0.05）。治疗后不同阶段组间比较，C组病损面积均小于A组和B组，疼痛程度评分和症状体征评分亦均低于A组和B组，差异有统计学意义（P＜0.05）；A组病损面积均小于B组，B组疼痛程度评分均低于A组，差异有统计学意义（P＜0.05）。治疗后1周，A组和B组症状体征评分差异无统计学意义（P＞0.05），治疗后2周和1个月，A组症状体征评分均低于B组，差异有统计学意义（P＜0.05）。 结论　曲安奈德口腔软膏联合半导体激光治疗牙龈LP的总体效果优于单独用药和单独使用激光，值得临床推广。

关键词: 牙龈扁平苔藓, 半导体激光, 曲安奈德口腔软膏
中图分类号：R78　文献标志码：A

Abstract:

Objective　To observe the clinical efficacy of semiconductor laser and triamcinolone acetonide dental paste in the treatment of gingival lichen planus. Methods　Totally 90 patients diagnosed with gingival lichen planus were randomly divided into 3 groups with 30 cases in each group. Group A：triamcinolone acetonide dental paste was given once a day for one month before going to bed；Group B：local irradiation of semiconductor laser was used，once per two days，15 times；Group C：triamcinolone acetonide dental paste and semiconductor laser were given--semiconductor laser irradiation was given first，one time every two days，15 times，and then ointment was used before bedtime，once a day. The treatment course was one month. Three groups of patients were compared before treatment，one week，two weeks and one month after treatment to observe the lesion area，pain degree，and symptoms and signs. SPSS 22.0 software was used to make statistical analysis. Results　After treatment，the lesion area of the three groups were reduced，and the scores of pain degree and symptoms and signs were reduced，the differences being statistically significant compared with before treatment （P < 0.05）. Intergroup comparison at different stages after treatment showed that the lesion area in group C was smaller than that in group A and group B，and the scores of pain degree and symptoms and signs in group C were lower than those in group A and group B， the differences being statistically significant （P < 0.05）；the lesion area in group A was smaller than that in group B，and the score of pain degree in group B was lower than that in group A，the differences being statistically significant（P < 0.05）. One week after treatment， there was no significant difference in symptoms and signs score between group A and group B （P＞0.05）. Two weeks and one month after treatment， the symptoms and signs score of group A was lower than that of group B（P < 0.05）. Conclusion　The overall effect of semiconductor laser and triamcinolone acetonide ointment in treating lichen planus with erosive gingiva is superior to that of using the ointment or laser alone，and it is worthy of clinical promotion.

Key words: gingival lichen planus, semiconductor laser, triamcinolone acetonide dental paste