中国实用口腔科杂志
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李晓琳,仇丽鸿
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沈阳市科学技术计划(F15-199-1-56)
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摘要:
明胶酶是基质金属蛋白酶(MMPs)家族的重要组成之一,包括MMP-2和MMP-9,是降解细胞外基质(ECM)的重要酶类。近年研究发现,明胶酶在牙髓炎和根尖周炎发病机制中起重要作用。文章就明胶酶的基础研究及其在牙髓炎和根尖周炎致病、诊断、治疗方面的研究进展做一综述。
关键词: 明胶酶, 基质金属蛋白酶-2, 基质金属蛋白酶-9, 牙髓炎, 根尖周炎
Abstract:
Gelatinases are the fundamental components of matrix metalloproteinases,including matrix metalloproteinase-2 and matrix metalloproteinase-9,and have the ability to degrade extracellular matrix. Recent studies have shown that gelatinases play an essential role in the pathogenesis of pulpitis and apical periodontitis. This paper makes a review on recent advances of the basic research of gelatinases and their effects on the pathogenicity,the diagnosis as well as the therapy for pulpitis and apical periodontitis.
Key words: gelatinases;matrix metalloproteinase-2, MMP-2;matrix metalloproteinase-9, MMP-9; pulpitis;apical periodontitis
李晓琳,仇丽鸿. 明胶酶与牙髓炎和根尖周炎相关性研究进展[J]. 中国实用口腔科杂志, DOI: 10.19538/j.kq.2017.02.013.
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http://www.zgsyz.com/zgsykqk/CN/Y2017/V10/I2/108