中国实用口腔科杂志

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高迁移率族蛋白B1与牙周病及糖尿病伴牙周病关系研究进展

单炜1综述,赵丽娟1,2审校   

  1. 作者单位:1.遵义医学院,贵州遵义563000;2.大连大学医学院,辽宁大连116021
  • 出版日期:2014-09-15 发布日期:2014-09-28
  • 通讯作者: 赵丽娟

Recent research progress of the correlation between HMGB1 and periodontal disease, HMGB1 and diabetes-associated periodontitis.

SHAN Wei*, ZHAO Li-juan   

  1. *Zunyi Medical College, Zunyi 563000, China
  • Online:2014-09-15 Published:2014-09-28

摘要:

高迁移率族蛋白B1 (high mobility group box 1 protein,HMGB1)作为高迁移率族蛋白(high mobility group protein,HMG)家族成员,是一种含量极为丰富的细胞核内非组蛋白。研究发现,其作为一种晚期炎性介质,在牙周病及糖尿病伴牙周病的发生发展过程起到重要作用。本文就HMGB1的生物学特性及其与牙周病、糖尿病伴牙周病等的关系研究进展做一综述。

关键词: 高迁移率族蛋白B1, 牙周病, 糖尿病伴牙周病

Abstract:

Abstract: High mobility group box 1 (HMGB1) as a member of high mobility group protein (HMG) family is one of the most abundant nuclear non-histone proteins. Recent studies have suggested that HMGB1 as a late inflammatory mediator plays a critical role in the occurrence and progression of periodontal disease and diabetes-associated periodontitis. This article will review the biological characteristics of HMGB1 and research status of relationship between HMGB1 and periodontal disease, HMGB1 and diabetes-associated periodontitis.

Key words: high mobility group box 1, periodontal disease, diabetes-associated periodontitis

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