Abstract:

Objective　To explore the safety and feasibility of pulmonary artery denervation（PADN） in children with idiopathic pulmonary hypertension（IPAH）. Methods　On July 11，2019，PADN was performed in Qingdao Women and Children’s Hospital on the bifurcation of main pulmonary artery and the opening of left and right pulmonary artery in a child with IPAH. The pressure and resistance of pulmonary artery were monitored after operation. Results　The pressure and resistance of pulmonary artery decreased significantly immediately after PADN. No serious complications occurred. Conclusion　PADN may be safe and feasible for children with IPAH. Further follow-up and multi-center registry study is necessary to confirm the efficacy and feasibility of PADN.

Key words: idiopathic pulmonary arterial hypertension, pulmonary artery denervation, child

摘要：

目的　探讨儿童特发性肺动脉高压（IPAH）行经皮肺动脉去神经术（PADN）的安全性及可行性。方法　青岛市妇女儿童医院于2019年7月11日为1例IPAH患儿在主肺动脉分叉处和左、右肺动脉开口处进行PADN治疗，术后监测肺动脉压力和阻力变化。结果　IPAH患儿PADN术后即刻肺动脉压力及血管阻力明显下降，无严重并发症发生。结论　PADN对IPAH患儿安全可行，但仍需要多中心、长时程随访研究来证实PADN的有效性和可行性。

关键词: 特发性肺动脉高压, 经皮肺动脉去神经术, 儿童