Abstract:

Objective　To compare the FeNO（Fractional exhaled nitric oxide，FeNO）of the children 3-5 years old by facemask with that by mouthpieces during tidal breathing，and to analyze the applicative value of the measurement for the children 3 to 5 years old. Methods　From Junuary 2016 to August 2016，the children who came to Guangzhou Women’s and Children’s Medical Center to take the FeNO experiment were selected as the research subjects. During tidal breathing，children used the facemask to cover their nose and mouth to breath，or word the nose clip and used the mouthpieces to breath during the FeNO test. After the test，the clinical data were summarized and analyzed. Results　The cases，which have no coughing and wheezing symptoms，whether with rhinitis or not，currently using the mouthpieces to measure the FeNO，were fewer than which using the facemask. The result of using mouthpieces and facemask to test in children with rhinitis was （7.8±10.6） ×10-9 vs. （15.8±9.9） ×10-9  and，without rhinitis it was （5.0±4.5） ×10-9 vs. （14.0±10.0） ×10-9 respectively，P＜0.05. The children having coughing or wheezing symptoms，whether with rhinitis or not，using the mouthpieces to measure the FeNO， was fewer than those using the facemask. The result of using mouthpieces and facemask to test in children with rhinitis was 6.1×10-9［（2.1～16.3） ×10-9 vs. 11.6×10-9［（4.1～26.5） ×10-9］  and in those without rhinitis it was 4.6×10-9［（1.9～9.9） ×10-9］ vs. 11.5×10-9［（6.5～25.8） ×10-9］ respectively，P＜0.05. All of them were statistically different. Conclusion　When we measure the FeNO in children from 3 to 5 years old during tidal breathing，breathing through the mouthpieces can reflect the airway inflammation better.

Key words: FeNO, preschool age, tidal breathing, methodology

摘要：

目的    对比3～5岁儿童清醒状态下，使用面罩潮气呼吸法和口腔潮气呼吸法所测出的呼出气一氧化氮（FeNO），探讨3～5岁儿童FeNO的检测方法。方法　将广州市妇女儿童医疗中心2016年1月至2016年8月符合入选标准的55例儿童作为研究对象，分别使用面罩潮气呼吸法和口腔潮气呼吸法进行FeNO检测，并对结果进行对比分析。结果　无咳喘症状儿童无论有无鼻炎，使用口腔潮气呼吸法测出的FeNO均明显低于面罩潮气呼吸法所测结果：分别使用口腔潮气呼吸法和面罩潮气呼吸法测FeNO，有鼻炎患儿为（7.8±10.6）×10-9 和（15.8±9.9）×10-9；无鼻炎患儿为（5.0±4.5）×10-9和（14.0±10.0）×10-9，均P＜0.05；有咳喘症状儿童，无论有无鼻炎，使用口腔潮气呼吸法测出FeNO明显低于面罩潮气呼吸法所测结果；分别使用口腔潮气呼吸法和面罩潮气呼吸法测FeNO，有鼻炎患儿为6.1×10-9 ［（2.1～16.3）×10-9］和11.6×10-9［（4.1～26.5）×10-9］，无鼻炎患儿为4.6×10-9［（1.9～9.9）×10-9］和11.5×10-9［（6.5～25.8）×10-9］，均P＜0.05。结论　3～5岁儿童使用潮气呼吸法进行FeNO检测时，口腔潮气呼吸法比面罩潮气呼吸法更能正确反应气道炎症真实情况。

关键词: 呼出气一氧化氮, 学龄前期, 潮气呼吸, 方法学