Abstract:

Asparaginase（Asp） is a critical agent used to treat acute lymphoblastic leukemia（ALL）. The basic information about Asp in ALL treatment such as efficacy and side effect，the administration of different kinds of Asps at home and abroad. As well as the three suggestions should be mastered by pediatricians for the improvement of the outcome of the ALL treatment.

Key words: Escherichia coli asparaginase, polyethylene glycol asparaginase, Erwinia asparaginase, acute lymphoblastic leukemia

摘要：

门冬酰胺酶（Asp）是治疗急性淋巴细胞白血病（ALL）的关键药物之一。临床医生应对Asp治疗ALL的基本概况，如药效、毒副反应等；不同类型门冬酰胺酶在国内外的使用情况；以及关于Asp治疗ALL的3点建议有所了解，以便提高临床疗效。

关键词: 大肠埃希菌源性门冬酰胺酶, 培门冬酶, 欧文菌源性门冬酰胺酶, 急性淋巴细胞白血病