Acta Metallurgica Sinica

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The role of regulatory B cells in rheumatic autoimmune diseases.

TANG Xue-mei.   

  1. Children's Hospital Affiliated to Medical University Of Chongqing,Key Laboratory of Pediatric Kidney Immune,Chongqing 400014,China
  • Online:2015-01-06 Published:2014-12-31

调节性B细胞与风湿免疫性疾病

唐雪梅   

  1. 作者单位:重庆医科大学附属儿童医院肾脏免疫科 儿科学重庆市重点实验室,重庆 400014
  • 基金资助:

    重庆市卫生计生委科研项目(2012-2-111)

Abstract:

Abstract: Human B lymphocytes play immune regulating function through producing specific antibodies and cytokines. Regulatory B cells play positive and negative immune regulatory roles by the secretion of various cytokines or cells contact mechanisms, and they play an important role of immune suppression in rheumatic autoimmune diseases, and may bring new hope to the patients with rheumatic autoimmune diseases.

Key words: regulatory B cells(Breg), B10 cells, rheumatic autoimmune disease, systemic lupus erythematosus(SLE), non-obese diabetes, rheumatoid arthritis(RA)

摘要:

人类B淋巴细胞主要通过分泌特异性抗体及细胞因子发挥免疫调节功能。调节性B细胞拥有正向和负向免疫调节作用,通过分泌不同的细胞因子或细胞接触等机制,完成下调免疫反应的作用。调节性B细胞在风湿免疫性疾病发生、发展中起着重要的免疫抑制作用,可能为风湿免疫病的治疗带来新希望。

关键词: 调节性B细胞, B10细胞, 风湿免疫性疾病, 系统性红斑狼疮, 非肥胖性糖尿病, 类风湿性关节炎

CLC Number: