Abstract:

Non-invasive high-frequency ventilation（NIHFV） is a newer form of non-invasive ventilation（NIV） which uses nasopharyngeal tubes，short nasal prongs or masks instead of endotracheal tube to deliver high frequency ventilation. NIHFV offers the advantages of invasive high frequency ventilation（no need for synchronisation，high CO2 removal，less volume/barotrauma） and nasal CPAP（non-invasive interface，increase in functional residual capacity allowing oxygenation to improve）. Clinical pilot studies show NIHFV can be used as a rescue therapy after failure of other NIV modes to help prevent or delay intubation. However，the data is limited. Further multi-center，prospective，randomized，controlled trials are needed.

Key words: non-invasive high-frequency ventilation, non-invasive ventilation, preterm neonate

摘要：

无创高频通气（NIHFV）是利用鼻塞、鼻咽管或面罩替代气管插管进行高频通气的一种新兴无创通气支持模式。NIHFV结合了经鼻持续气道正压通气（NCPAP）和高频通气（HFV）的优点，具有持续维持肺泡稳定，更有利于清除CO2，压力伤更小，不需要同步技术等优势。小样本研究表明NIHFV可作为其他无创通气失败后的营救性治疗从而避免和延迟气管插管，但是目前临床资料有限，需要进一步的多中心、大样本、随机对照研究。

关键词: 无创高频通气, 无创通气, 早产儿