关键词: 药物性肾损伤, 急性肾损伤, 慢性肾脏病, 儿童

Abstract:

Drug-induced kidney injury is one of the main causes of acute kidney injury in children. Certain drugs can lead to tubular epithelial injury，kidney immune inflammation，or alter the intraglomerular hemodynamics，or cause intrarenal obstruction，which contribute to clinical manifestations including acute kidney injury，acute tubular necrosis，acute or chronic interstitial nephritis，nephrolithiasis/crystal nephropathy，nephrotic syndrome，tubular dysfunction，et al. The setting of several biomarkers are used for prediction and detection of early drug-induced kidney injury. In clinical practice the risk factors of drug-induced kidney injury should be corrected in time and the related drugs be stopped and kidney function be monitored in order to achieve early diagnosis and early intervention，which can improve the prognosis.