中国实用儿科杂志

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儿童心肌病发病机制研究进展

邹润梅王成   

  1. 作者单位: 中南大学湘雅二医院儿童医学中心儿童心血管专科/中南大学儿科学研究所, 湖南 长沙 410011
  • 出版日期:2014-09-02 发布日期:2014-09-04

Current pathogenesis of cardiomyopathy in children.       

ZOU Run-meiWANG Cheng.   

  1. Department of Cardiovascular Pediatrics,Second Xiangya Hospital of Central South University, Institute of Pediatrics of Central South University, Changsha 410011,China
  • Online:2014-09-02 Published:2014-09-04

摘要:

心肌病是一组以心肌结构和功能异常为特征的异质性心肌疾病,其发病机制尚不明确。心肌病发病涉及基因缺陷、先天性代谢缺陷、心脏先天发育缺陷、炎症反应及自身免疫机制等多方面,且这些因素相互作用,其中基因缺陷起着主导作用。上述机制的具体作用有待深入研究。

关键词: 心肌病, 发病机制, 儿童

Abstract:

Abstract: Cardiomyopathies are defined as heterogeneous diseases of myocardium with associated structural and functional abnormalities, and their pathogenesis is unclear. Pathogenesis of cardiomyopathies involves genetic defect,congenital metabolic defects,congenital heart defect,inflammation reaction,autoimmune disorder and so on. All these mechanisms work together, among which genetic defect is the dominant factor. Further study in pathogenesis of cardiomyopathy is helpful to provide new ideas for the specific treatment of cardiomyopathy.

Key words: cardiomyopathy, pathogenesis, children

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