中国实用儿科杂志

中国实用儿科杂志

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《儿童过敏性鼻炎诊疗——临床实践指南》发病机制部分解读

  

  1. 1.山东大学齐鲁儿童医院耳鼻喉科，山东  济南  250022；2. 山东大学附属省立医院耳鼻喉科，山东  济南  250021
  • 出版日期:2019-03-06 发布日期:2019-07-03

Interpretation of the pathogenesis part of Clinical Practice Guideline：Diagnosis and Treatment in Children with Allergic Rhinitis

  1. *Department of E.N.T， Qilu Children’s Hospital of Shandong University， Ji’nan  250022， China
  • Online:2019-03-06 Published:2019-07-03

摘要：

儿童过敏性鼻炎是机体暴露于变应原后发生的、主要由免疫球蛋白E（IgE）介导的鼻黏膜非感染性慢性炎性疾病。过去认为Th1/Th2免疫失衡是过敏性鼻炎的主要发病机制，但是越来越多的研究强调疾病个体的免疫系统的整体性。对儿童过敏性鼻炎的天然免疫和获得性免疫学发病机制进行系统性讨论，也许能为更有效治疗该类疾病的患儿提供方向。

关键词: 过敏性鼻炎, 天然免疫, 获得性免疫, 免疫学发病机制

Abstract:

Allergic rhinitis（AR） in children is non-infectious chronic inflammatory disease in the nasal mucosa which was largely determined by IgE when the body is exposed to allergens. It was believed that Th1/Th2 immune imbalance is the main pathogenesis of AR；however，more and more studies put emphasis on the integrality of individual immune system of the disease. Systematic discussion on the pathogenesis of natural immunity and acquired immunity in allergic rhinitis may provide useful AR treatments in the future.

Key words: allergic rhinitis, natural immunity, acquired immunity, immunopathogenesis