关键词: 脓毒症, 凝血功能障碍, 抗凝治疗, 微血栓形成, 弥散性血管内凝血

Abstract:

Sepsis is a major problem in the field of critical illness. One of the important reasons for the death of sepsis is the disorder of coagulation function，especially in the case of DIC. Coagulation dysfunction is always in the pathological process of sepsis，and its occurrence and prognosis is an important and independent prognostic factor. The activation of coagulation system and inflammatory response promote each other，and the inhibition of physiological anticoagulant system and fibrinolysis system are the pathophysiological basises of coagulation dysfunction in sepsis. Therefore，the anticoagulant therapy of sepsis has sufficient theoretical basis. However，there is no consistent conclusion about the treatment of sepsis at present. This article will discuss the mechanism of coagulation dysfunction and the research progress of anticoagulation therapy.

Key words: sepsis, coagulopathy, anticoagulant therapy, thrombosis, disseminated intravascular coagulation