关键词: 血液净化, 肾替代治疗, 脓毒症, 儿童

Abstract:

Hemofiltration and renal replacement therapy are usually preferred as adjunct therapy for sepsis to improve hemodynamics and fluid balance，as well as to remove noxious molecules and inflammatory factors. It is well known that continuous renal replacement therapy（CRRT） is an important adjunct therapy for sepsis-associated kidney injury. Recently， blood purification is widely used to treat septic shock， acute respiratory distress syndrome（ARDS）， severe acute pancreatitis and electrolyte imbalance. Currently， there are four different patterns of blood purification used including continuous veno-venous hemofiltration（CVVH）， high volume hemofiltration（HVHF）， continuous veno-venous hemodiafiltration（CVVHDF） and plasma exchange（PE） in pediatric sepsis. However，there is no standard recommendation for blood purification model and the optimal timing in pediatric sepsis.

Key words: hemofiltration, renal replacement therapy, sepsis, child