关键词: 感染性腹主动脉瘤, 虚弱, 5因子改良衰弱指数, 预后结局

Abstract: To evaluate the impact of the 5-factor modified frailty index (mFI-5) on the prognosis of patients with infectious abdominal aortic aneurysm, aiming to assist in clinical decision-making and prognostic assessment. Methods    The clinical data of 100 patients with infected abdominal aortic aneurysm at the Department of Vascular Surgery, the First Affiliated Hospital of China Medical University from March 2011 to November 2022 were retrospectively analyzed, and the patients who met the inclusion and exclusion criteria were included in the study. They were divided into three groups according to the mFI-5 score（mFI-5=0，mFI-5=1，mFI-5≥2）, and the differences in baseline data, primary outcomes, and secondary outcomes among the three groups were compared. Results    There were no statistically significant differences in baseline characteristics such as age range, smoking history, and surgical plan among the groups (P>0.05). There were no statistically significant differences among the three groups in the incidence of infectious abdominal aortic aneurysm-related reintervention, acute renal failure, blood transfusion for bleeding, cerebral hemorrhage, gastrointestinal hemorrhage, lower extremity arterial thrombosis, and sepsis. The 1-year and 5-year all-cause mortality, IAAA-related mortality, postoperative myocardial infarction, and postoperative ventilator use ≥48 hours were significantly higher in patients with infected abdominal aortic aneurysm with mFI-5 score ≥2 than those in the other two groups, and the difference was statistically significant (P<0.05). Conclusion  The mFI-5 score is associated with all-cause and IAAA-related mortality, postoperative myocardial infarction, and postoperative ventilator use for ≥48 hours. The mFI-5 score may be a useful screening tool for the surgical treatment of frail patients with infected abdominal aortic aneurysms.

Key words: infectious abdominal aortic aneurysm, frailty, 5-factor modified frailty index, prognostic outcome