中国实用外科杂志

中国实用外科杂志 ›› 2022, Vol. 42 ›› Issue (05): 585-589.DOI: 10.19538/j.cjps.issn1005-2208.2022.05.21

• 论蓍 • 上一篇    下一篇

海德堡胰腺癌预后评分对胰腺癌根治性切除术后病人预后的评估价值分析

谢    彧1，杭和兴1，李    刚2，褚薛慧2，毛    谅2，程    浩2，仇毓东2   

  1. 1南京大学医学院，江苏南京 210008；2南京大学医学院附属鼓楼医院肝胆胰中心，江苏南京 210008
  • 出版日期:2022-05-01 发布日期:2022-05-17

  • Online:2022-05-01 Published:2022-05-17

摘要： 目的    探讨海德堡胰腺癌预后（HELPP）评分对胰腺癌根治性切除术后病人预后的评估价值。方法    回顾性分析2019年3~12月在南京大学医学院附属鼓楼医院肝胆胰中心接受根治性手术的35例胰腺癌病人的临床资料和随访资料。根据术前HELPP评分将病人分为低分组（≤3分）和高分组（＞3分），比较两组病例临床病理资料，绘制生存曲线并比较两组病人的术后生存时间差异。结果    35例病人中，低分组有21例，高分组有14例，两组病人在性别、年龄、肿瘤部位、肿瘤大小、病理学分期、是否合并糖尿病、是否行辅助治疗以及R0切除率等方面比较差异均无统计学意义。所有病人均有完整随访资料，中位随访时间为29.0个月。低分组和高分组术后中位总生存期分别为29.0个月和15.0个月，差异有统计学意义（P<0.05）。结论    术前HELPP评分可考虑作为预测根治性切除胰腺癌病人预后的工具，评分高可能提示预后不良，但仍需进一步扩大样本量进行验证。

关键词: 胰腺癌, 海德堡胰腺癌预后评分, 预后

Abstract: Prognostic value of Heidelberg Prognostic Pancreatic Cancer (HELPP)-score in patients with pancreatic cancer undergoing radical resection        XIE Yu*, HANG He-xing, LI Gang,  et al. * Nanjing University Medical School, Nanjing 210008, China
Corresponding author: CHENG Hao, E-mail: ch3320323@163.com
Abstract    Objective    To investigate the value of the Heidelberg Prognostic Pancreatic Cancer (HELPP)-score in evaluating the prognosis of patients with pancreatic cancer after radical resection. Methods    The clinical data and follow-up data of 35 patients with pancreatic cancer who underwent curative surgery between March and December 2019 at the Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, were retrospectively reviewed. According to the preoperative HELPP-score, these patients were divided  into a low-point group (≤ 3 points) and a high-point group(> 3 points).  Clinicopathological data in the two groups were compared. Kaplan-Meier curve was used to estimate the median overall survival time and the Log-rank test was utilized for comparison between the two groups. Results    Of the 35 patients, 21 were in the low-point group and 14 were in the high-point group. There were no statistically significant differences in sex, age, tumor location, tumor size, pathological stage, comorbid diabetes mellitus, adjuvant therapy, and R0 resection rate between the two groups. The follow-up data of all patients were complete and the median follow-up time was 29.0 months. The median overall survival was 29.0 months and 15.0 months in the low-point group and the high-point group respectively, and the difference was statistically significant (P<0.05). Conclusion    Preoperative HELPP-score can be considered a tool to predict the prognosis in patients with resectable pancreatic cancer. High scores may indicate a poor prognosis, but it is necessary to be validated in a larger-scale study.

Key words: pancreatic cancer, Heidelberg Prognostic Pancreatic Cancer score, prognosis