关键词: 胰腺神经内分泌肿瘤, 肝转移, 介入治疗, 化学治疗

Abstract:

Treatment strategy of pancreatic neuroendocrine neoplasms with liver metastasis        CHEN Luo-hai，CHEN Jie. Department of Gastroenterology，the First Affiliated Hospital of Sun Yat-sen University，Guangzhou 510080，China
Corresponding author: CHEN Jie，E-mail: chen0jie@hotmail.com
Abstract    About 20% to 64% of patients with pancreatic neuroendocrine neoplasms (panNEN) had advanced disease with liver being the most common location of distant metastasis. Liver metastasis is not the contraindication of surgery. Curative resection should still be considered in patients with G1 or G2 disease. In respect of patients with unresectable disease, systematic therapy or nuclide therapy combined with intervention treatment should be applied while liver transplantation can be used only in a small number of selected patients. Temozolomide monotherapy or combined with capecitabine may be effective in patients with well differentiated G3 pancreatic neuroendocrine tumor. As for pancreatic neuroendocrine carcinoma, platinum-based chemotherapy is the first-line treatment option.

Key words: pancreatic neuroendocrine neoplasms, liver metastasis, intervention treatment, chemotherapy