关键词: 胃肠间质瘤, 术前治疗, 新辅助治疗, 转化治疗, 靶向治疗

Abstract:

Application of preoperative target therapy and the timing of surgery for gastrointestinal stromal tumor        LI Zi-yu, LI Shuang-xi, JI Jia-fu.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)；Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China
Corresponding author: LI Zi-yu, E-mail: ziyu_li@hsc.pku.edu.cn
Abstract    With the progression in pathogenesis and drug developments, the emergence of small molecule tyrosine kinase inhibitor (imatinib) changed the treatment modality of gastrointestinal stromal tumors (GIST), which centered on surgery mainly in the past. For the locally advanced or metastatic disease, the preoperative treatment could increase resection rate, preserve organ function, decrease recurrence, and even bring survival benefits. However, preoperative treatment of GIST still lacks large sample prospective randomized study data. Various studies have significant differences in patients' enroll standard, dosage, time, evaluation and adjuvant therapy. There are still many controversies about the duration of the preoperative treatment of GIST and timing of surgery.

Key words: gastrointestinal stromal tumor, preoperative treatment, neoadjuvant treatment, conversion treatment, target therapy