关键词: 胃肠间质瘤, 靶向治疗, 晚期肿瘤, 复发

Abstract:

Role of surgery in the treatment of advanced and recurrent gastrointestinal stromal tumors        SHEN Kun-tang,GAO Xiao-dong. Department of General Surgery, Zhongshan Hospital，Fudan University; Institute of General Surgery of Fudan University, Shanghai 200032, China
Corresponding author: SHEN Kun-tang, E-mail:shen.kuntang@zs-hospital.sh.cn
Abstract    At present, the prognosis of advanced and recurrent gastrointestinal stromal tumors is poor. Target therapy is the first choice for treatment, but surgical treatment is still an important component. Surgery is the only effective treatment for GISTs who are not adapted to target drug therapy. For patients with locally advanced GISTs, preoperative target therapy combined with surgical treatment is beneficial to radical resection of tumor and preservation of important organs. For tumor progression among patients with metastatic and/or recurrent GISTs, cytoreduction before imatinib therapy does not appear to improving the prognosis. For patients with advanced GISTs exhibiting stable disease or response on kinase inhibitor therapy, progression free survival and overall survival are prolonged after debunking procedures. The benefits of surgery for locally progressive GIST during imatinib therapy are still in discussion. Surgery can be chosen according to the patients’ desire and surgeon’s experience. Surgery is not recommended for the patients who are generalized progression, because it has little benefit for progression free survival and overall survival.

Key words: gastrointestinal stromal tumor, target therapy, advanced tumor, recurrence