中国实用外科杂志

• 专题笔谈 • 上一篇    下一篇

肉芽肿性乳腺炎的诊断与处理原则

王    颀,杨剑敏于海静   

  1. 广东省妇幼保健院乳腺病中心,广东广州 510010
  • 出版日期:2016-07-01 发布日期:2016-06-23

  • Online:2016-07-01 Published:2016-06-23

摘要:

肉芽肿性乳腺炎不常见,但文献报告近年有增加趋势。临床特征为育龄经产妇突发乳腺肿块,脓肿形成,继发窦道和溃疡,可反复发作或经久不愈。棒状杆菌感染可使病程变得复杂。经皮活检是主要的确诊方法,病理特征为以小叶为中心组织细胞的上皮样和多核巨细胞浸润的非干酪样肉芽肿伴微脓肿,但须做排除性诊断。根据不同临床表现、细菌学检查和病理学检查进行分类,随后可行手术、激素治疗后手术和抗分枝杆菌治疗以及免疫抑制剂治疗等分类处理。

关键词: 肉芽肿性乳腺炎, 棒状杆菌, 激素治疗, 抗分枝杆菌药物

Abstract:

Granulomatous mastitis: diagnonsis and treatment                     WANG Qi,YANG Jian-min,YU Hai-jing. Breast Center of Guangdong Women and Children Hospital,Guangzhou 510010,China
Corresponding author: WANG Qi,E-mail: 2307057220@qq.com
Abstract    Granulomatous mastitis is an uncommon condition,but increasing from articles published. In parous women of reproductive age,clinically,it can present as breast mass,abcess formation with features, and progression to sinus or skin ulcer that may relapse and prolonged unhealed. Corynebacterium infection can result in more complicated the process. Percutaneous biopsy is the main diagnostic methods of granulomatous mastitis which is characterised histopathologically by the presence lobulecentred non-caseating granuloma surrounded by epithelioid histiocytes and multinucleated giantcells, and microabscess formation. However,other diseases must be excluded. On the basis of the differental presentation, microbiology and biopsy evalution, surgeons could classify granulomatous mastitis. Subsequently,conventional surgery, surgical excision after steroid therapy,and anti-mycobacterium drug and immunosuppressive treatment regimen can be carried out for individual treatment.

Key words: granulomatous mastitis;corynebacterium;steroids therapy; , anti-mycobacterium drug