中国实用外科杂志

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多学科联合诊疗时代局部进展期胰腺癌的处理

白雪莉1,马    涛1,梁廷波12   

  1. 1浙江大学医学院附属第二医院肝胆胰外科,浙江杭州310009;2浙江大学癌症创新协同中心,浙江杭州 310058
  • 出版日期:2016-05-01 发布日期:2016-04-28

  • Online:2016-05-01 Published:2016-04-28

摘要:

根治性切除是延长胰腺癌病人生存期的最有效手段,但大部分胰腺癌在初诊时即为局部进展期或伴有远处转移而无法行手术切除。以外科为中心的多学科综合治疗协作组联合诊治,通过制定规范化、连续性的最优诊疗方案有望使局部进展期胰腺癌降期,从而获得根治性切除的机会。这套系统性的诊疗方案包括充分的影像学评估、准确的病理学诊断、个体化的新辅助治疗、手术及术后的辅助治疗,实践证明其对局部进展期胰腺癌的效果斐然。

关键词: 胰腺癌, 局部进展期, 多学科联合诊治, 多学科综合治疗协作组

Abstract:

Management of locally advanced pancreatic cancer in the era of multidisciplinary diagnosis and treatment        BAI Xue-li, MA Tao, LIANG Ting-bo. Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Corresponding author: LIANG Ting-bo. E-mail: liangtingbo
@zju.edu.cn
Abstract    Radical resection of pancreatic cancer offers the best chance for prolonged survival. Pancreatic resections are not eligible in most cases of pancreatic cancer owing to locally advanced stage or distal organ metastasis. Surgery-oriented multidisciplinary diagnosis and treatment for locally advanced pancreatic cancer (LAPC) may downgrade the tumor to be potentially resectable by offering individualized optimal therapies. Such multidisciplinary management includes adequate imaging evaluation, and pathological diagnosis, neoadjuvant chemo-(radio) therapies, subsequent surgery, and adjuvant therapies. It has been proven to be efficient in managing LAPC. In the article, the authors reviewed recent progress and made some comments on multidisciplinary management of LAPC based on our experience.

Key words: pancreatic cancer, locally advanced stage, multidisciplinary diagnosis and treatment;multidisciplinary team