中国实用外科杂志

中国实用外科杂志 ›› 2012, Vol. 32 ›› Issue (01): 36-39.

• 普通外科进展 • 上一篇    下一篇

胃肠间质瘤及其转化医学

张信华，何裕隆，詹文华   

  1. 中山大学附属第一医院胃肠胰外科 胃肠间质瘤诊治中心，广东广州 510080
  • 出版日期:2012-01-01 发布日期:2011-12-29

  • Online:2012-01-01 Published:2011-12-29

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摘要：

胃肠间质瘤是近年重新认识并且在治疗上取得较大突破的实体肿瘤类型。从发现其主要的发病机制开始，不久即出现了针对性的治疗药物，成为最早进入“靶向治疗”的肿瘤类型之一，体现了转化医学倡导的从实验室研究成果到临床应用的快速转化。回顾10余年来对该病的认识与诊治过程，本身就是对于肿瘤转化医学这一新兴的医学研究模式极佳的诠释。

关键词: 胃肠间质瘤, 转化医学, 基因突变, 靶向治疗

Abstract:

Gastrointestinal stromal tumors and translational medicine        ZHANG Xin-hua, HE Yu-long, ZHAN Wen-hua. Department of Gastrointestinal and Pancreatic Surgery, the First Affiliated Hospital of Sun Yat-sen Univercity, Guangzhou 510080, China
Corresponding author: ZHAN Wen-hua, E-mail: wenhuazhan@medmail.com.cn
Abstract    Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Gain-of-function mutations on tyrosine kinase receptor are the keys of oncogenesis in GIST, which become the target of therapy, as well as the mechanism of drug resistance. A decade of progress in clinical management of GIST becomes a model of   translational medicine research, which advocates rapid conversion from the laboratory achievement to clinical application.

Key words: gastrointestinal stromal tumor, translational medicine, gene mutation, targeted therapy