关键词: 转化医学, 肝移植后急性移植物抗宿主病, 调节性T细胞

Abstract:

The translational medicine study for acute graft-versus-host-disease after liver transplantation        LIANG Ting-bo, XIA Xue-feng. Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310009,China
Corresponding author: LIANG Ting-bo, E-mail: liangtingbo@zju.edu.cn
Abstract    Translational medicine is a novel concept internationally and it focus on transferring achievement of basic research to clinical setting. The scientific idea of preclinical study often originates from clinical work. Acute graft-versus-host disease after liver transplantation is a challenging problem in the clinical practice because of its high mortality. The real mechanism of this disease is unclear at present. Since its low incidence, it is necessary to document the mechanism experimentally. We did related research work in lab recently, which included rat model establishment, immune problem and modalities exploring et al. The preclinical research results are pending to apply in clinical setting. Our work is a typical example of translational medicine. From this view point, here we summarize some issues.

Key words: translational medicine, acute graft-versus-host disease after liver transplantation, regulatory T cells