中国实用外科杂志

中国实用外科杂志 ›› 2011, Vol. 31 ›› Issue (09): 778-780.

• 专题笔谈 • 上一篇    下一篇

慢性胰腺炎的病因和发病机制

王兴鹏1，张汝玲2   

  1. 1同济大学附属第十人民医院，上海200072；2上海交通大学附属第一人民医院，上海200080
  • 出版日期:2011-09-01 发布日期:2011-08-19

  • Online:2011-09-01 Published:2011-08-19

PDF

摘要：

慢性胰腺炎可由多种因素所致，以胰腺组织结构的进行性、不可逆性损害和内外分泌功能不全为主要表现。胰腺纤维化为其典型的病理学改变，临床表现有反复发作的腹痛及胰腺内、外分泌功能不全等。与慢性胰腺炎相关的病因及危险因素主要包括胆石病、酗酒、遗传因素、自身免疫因素等，其发病机制仍不甚明确，临床中慢性胰腺炎的发生更是多种病因、多种发病机制共同作用的结果。进一步研究慢性胰腺炎的具体病因及发病机制，对预防和治疗慢性胰腺炎具有重要意义。

关键词: 慢性胰腺炎, 病因, 发病机制

Abstract:

Etiology and pathogenesis of chronic pancreatitis                     WANG Xing-peng*, ZHANG Ru-ling. *Tenth People’s Hospital of Tongji University, Shanghai 200072, China
Corresponding author: WANG Xing-peng, E-mail: wangxp1965@yahoo.com.cn
Abstract    Chronic pancreatitis (CP) is the progressive and permanent destruction of the pancreas resulting in exocrine and endocrine insufficiency. The typical pathological change of CP is pancreatic fibrosis, which could cause persistent or recurrent abdominal pain as well as loss of pancreatic endo- and exocrine function. The etiology and pathogenesis of CP are multifactorial, including cholelithiasis, alcoholism, genetic predisposition and autoimmune factors. However, the incidence of CP should be a result of multiple etiological factors, and the individual pathogenesis remains unclear. Further researches of individual etiology and pathogenesis of CP would be helpful to the prevention and treatment of this disease.

Key words: chronic pancreatitis, etiology, pathogenesis