关键词: 肿瘤, 分子靶向治疗

Abstract:

Types of tumor molecular targeted therapies and mechanisms of action        WANG Ya-jie，WANG Ning. Department of Oncology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Corresponding  author：WANG Ya-jie，E-mail:yajiewa0459@163.com
Abstract    The mechanisms of action and toxicities of molecular targeted therapies differ from those of traditional cytotoxic chemotherapy. The therapies have expanded the concept of individually tailored cancer treatment because some of the drugs may be effective in patients whose cancers have a specific molecular target also resulting in less toxicity to healthy cells in the body. Their distinct mechanisms of action have significantly changed the treatment of cancer over the past 10 years. The two main types of targeted therapies are monoclonal antibodies and small molecule inhibitors that they would inhibit receptor tyrosine kinases (RTKs), nonreceptor kinases, the angiogenic molecules, the enzymes involved in extracellular matrix degradation.

Key words: tumor, molecular targeted therapies