关键词: 胃肠间质瘤, 外科手术, 靶向治疗, 甲磺酸伊马替尼

Abstract:

Diagnosis and treatment of gastrointestinal stromal tumors (GIST) :an analysis of 87 cases        LU Qi, LI Wei-ping, Cheng Ai-qun,et al. Department of Surgery, Huadong Hospital, Shanghai Fudan University School of Medicine, Shanghai200040, China
Corresponding author: LI Wei-ping, E-mail:weipingli789@hotmail.com
Abstract    Objective    To study the diagnosis and treatment of gastrointestinal stromal tumors （GIST）．Methods    The clinical data of 87 cases of GIST proved pathologically admitted from January 2000 to December 2008 at Huadong Hospital, Shanghai Fudan University School of Medicine were analyzed retrospectively．Results    The tumors originated respectively from the esophago（n=1）, stomach(n=45)，duodenum (n=3)，intestine(n=23)， colon (n=3), rectum (n=3) and pelvic cavity(n=9)．Seven cases of gastric GIST were performed by laparoscopic lumpectomy. One case of rectal GIST was resected transanally. Seventy-nine cases of GIST were performed by laparotomy. Eight of them underwent palliative resection or biopsy because of extensive metastasis．Senventy-one cases were resected completely. There was no operative mortality. Fifty-five cases were followed-up. Thirteen cases had recurrenced and metastisis,and 10 of them were liver metastisis. Conclusion    Curative resection is the first choice for treatment of GIST．The cases of malignant GIST or potential malignant GIST must be performed adjuvant therapy with imatinibmesylate．

Key words: gastrointestinal stromal tumour, surgical procedures, target therapy, imatinibmesylate