中国实用外科杂志

中国实用外科杂志 ›› 2009, Vol. 29 ›› Issue (10): 850-852.

• 论著 • 上一篇    下一篇

区域动脉灌注治疗重症急性胰腺炎45例临床研究

周蒙滔1，张启瑜1，王春友2，朱椰凡1，孙洪伟1，余正平1   

  1. 1温州医学院附属第一医院肝胆胰外科，浙江温州325000；2华中科技大学同济医学院附属协和医院，湖北武汉430030
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-10-01 发布日期:2009-10-01

  • Received:1900-01-01 Revised:1900-01-01 Online:2009-10-01 Published:2009-10-01

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摘要：

目的 探讨早期区域动脉灌注（RAI）治疗重症急性胰腺炎（SAP）的临床疗效。方法 分析1999 年8 月至2007 年6 月期间温州医学院附属第一医院外科收治的45 例采用早期RAI 治疗的SAP 病人的病情、灌注药物、联合手术治疗以及临床疗效。结果 （1）病死率为4.4%；（2）并发症发生率为35.6%；（3）全组平均住院时间29.4d，其中单纯RAI 的33 例为23.1d，联合手术的12 例为39.0d；（4）全组平均医疗费用6.01 万元，其中单纯RAI 的33 例为4.43 万元，联合手术的12 例为10.34 万元；（5）全组坏死继发感染发生率为28.9%。结论 早期RAI 能降低SAP病死率、减少并发症、缩短住院时间、降低医疗费用，是治疗SAP的一项增效的非手术方法。

关键词: 重症急性胰腺炎, 动脉内灌注

Abstract:

Clinical research on regional intra-arterial infusion for the treatment of severe acute pancreatitis ZHOU Meng-tao*, ZHANG Qi-yu, WANG Chun-you, et al. *Department of Hepatobiliary & Pancreatic Surgery, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China Corresponding author: ZHANG Qi-yu, E-mail: qiyuz@126.com Abstract Objective To study the the rapeutic effect of regional arterial infusion（RAI）on severe acute pancreatitis (SAP) on early stage. Methods Forty-five cases of SAP were treated with RAI on early stage between August 1999 and June 2007 at the First Affiliated Hospital of Wenzhou Medical College. Then the state of illness, drugs infused, combined surgery and therapeutic effect were analyzed. Results ⑴The fatality rate was 4.4%. ⑵The incidence rate of complication was 35.6%(16/45).⑶The average length of hospital stay of total cases was 29.4 days; thereinto, the average length of hospital stay of the 33 cases with only RAI, 12 cases with RAI combined surgery was 23.1 days and 39.0 days, respectively. ⑷The average medical cost of total cases was 60.1 thousand yuan RMB; thereinto, the average medical cost of 33 cases with only RAI, 12 cases with RAI combined surgery was 44.3 thousand yuan RMB and 103.4 thousand yuan RMB, respectively. ⑸The incidence rate of secondary infection of total cases was 28.9%. Conclusion RAI can bring down the fatality rate, reduce the incidence rate of complications, shorten hospital stays, reduce medical cost. It is a synergistic non-operation therapeutic method of SAP.

Key words: severe acute pancreatitis, regional arterial infusion