中国实用外科杂志

中国实用外科杂志 ›› 2009, Vol. 29 ›› Issue (06): 495-498.

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前列腺素E1治疗急性胰腺炎的系统评价

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  1. 兰州大学 a.第一医院，b.循证医学中心，c.基础医学院，甘肃兰州 730000
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-06-10 发布日期:2009-06-10

  • Received:1900-01-01 Revised:1900-01-01 Online:2009-06-10 Published:2009-06-10

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摘要：

目的 评价前列腺素E1治疗急性胰腺炎的临床疗效和安全性。方法 通过计算机检索全面收集 （1966年1月至2008年10月）全世界关于前列腺素E1治疗急性胰腺炎的随机对照试验或半随机对照试验,并辅手工检索和其他检索。按照纳入排除标准纳入文献,由2名研究者独立筛选并提取资料,采用Handbook 4.2.6推荐的质量评价标准评价纳入研究的质量,采用Rev Man 4.2.10软件进行统计学处理。 结果 最终纳入5项研究310例病人。Meta分析结果显示前列腺素E1+常规治疗组与常规治疗组比较, 在腹痛缓解时间、腹痛完全消失时间、血清淀粉酶恢复正常时间、治愈时间方面差异有统计学意义。结论 当前研究显示，前列腺素E1+常规治疗能显著缩短急性胰腺炎病人的腹痛缓解时间、腹痛完全消失时间、血清淀粉酶恢复正常时间和治愈时间。

关键词: 前列腺素, 急性胰腺炎, 系统评价

Abstract:

Alprostadil for acute pancreatitis: a systematic review LI Qiang* , CAO Nong, YANG Ke-hu, et al. *The First Hospital of Lanzhou University, Evidence Based Medicine Center of Lanzhou University, Lanzhou 730000,China Corresponding author: CAO Nong, E-mail: caonong2008@yahoo.com.cn Abstract objective To asses the effectivity and safety of alprostadil plus conventional treatment for the acute pancreatitis. Methods It searched related database and identified randomized controlled trials or quasi-randomize controlled trials of alprostadil plus conventional treatment versus conventional treatment for the acute pancreatitis. It evaluated the quality of the included studies by handbook 4.2.6,which recommend by cochrane collaboration. The data analysis was conducted by using Rev Man 4.2.10. Results Five randomized controlled trials (n=310) were included. The Meta analysis showed that there were significant difference between two groups in terms of abdomen pain’s relieving, the time of abdomen pain complete disappeared, serum amylase return to normal and period of cure. Conclusion The current evidence shows that alprostadil plus conventional treatment can significantly reduce the time of acute pancreatitis abdomen pain’s relieving, the time of abdomen pain complete disappeared, serum amylase return to normal and period of cure.

Key words: alprostadil, acute pancreatitis, systematic review