关键词: 腹腔感染, 肠外瘘, 腹腔开放

Abstract:

Open abdomen technique in the management of gastrointestinal fistula complicated with severe intra-abdominal infection REN Jian-an Research Institute of General Surgery, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, China Abstract Objective To investigate the result of open abdomen technique in the treatment of gastrointestinal fistula complicated with severe intra-abdominal infection. Methods The clinical data of 73 gastrointestinal fistula patients complicated with severe intra-abdominal infection received open abdomen therapy from January 1999 to December 2008 at Nanjing General Hospital of Nanjing Military Command of PLA were analyzed retrospectively. Results Fifty-six of 73 patients (76.7%) survived to discharge. Ten patients (13.7%) died and 7 patients ( 9.6%) gave up the treatment. The main causes of death were hemorrhage of abdominal cavity (5 cases), infection and organ nonfunction (5 cases). The average APACHEII score for survivors was 13.5±4.3 before open abdomen and dropped to 9.2±4.5 and 8.1±6.2 after 5 and 15 days of open abdomen. The average APACHEII score for dead patients was 16.0±5.8 before open abdomen and dropped to 12.9±5.5 and increased to 16.3±11.8 after 5 and 15 days of open abdomen. The score of organ function changed similarly .Conclusion The open abdomen therapy is an effective treatment for gastrointestinal fistula complicated with severe intra-abdominal infection. Open abdomen could improve the severity score of severe intra-abdominal infection patients. The therapy can be divided into three stages including temporary closure of the open abdomen, skin graft of open wound and permanent closure of abdomen and resection of enteric fistula. The reconstruction operation of digestive tract and abdominal wall can be performed simultaneously.

Key words: intra-abdominal infection, enterocutaneou fistula, open abdomen