中国实用外科杂志

中国实用外科杂志 ›› 2009, Vol. 29 ›› Issue (08): 659-661.

• 论著 • 上一篇    下一篇

胰腺癌外科治疗影响病人生存相关因素分析

侯宝华，区金锐   

  1. 广东省医学科学院 广东省人民医院肝胆胰外科， 广东广州510080
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-08-01 发布日期:2009-08-01

  • Received:1900-01-01 Revised:1900-01-01 Online:2009-08-01 Published:2009-08-01

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摘要：

目的 探讨胰腺癌的手术方式、病理分期、淋巴结转移、血管侵犯对病人存活率、生存时间的影响。 方法回顾性分析广东省人民医院1996年1月至2006 年10月收治的50例胰腺癌病人随访资料。应用SPSS13.0统计软件包进行统计学分析。结果 1、3、5年累计存活率63.0%，24.0%，12.0%，手术死亡率和术后总并发症发生率为4.0%和38.0%。COX回归分析手术方式和病理分期对生存时间及累计存活率的影响有统计学意义（P<0.05）。R0切除（根治性切除）组的中位生存时间和3 、5 年累计存活率分别为30个月、41.0 %、20.0 %，明显高于R1和R2切除组，差异具有统计学意义（P<0.05）。Ⅰ期病人3、5 年累计存活率分别为49.0 %、28.0 %。结论 早诊断、早治疗可以明显提高病人R0切除率、中位生存时间和存活率。R0切除仍是目前惟一有效、安全的治疗方法。

关键词: 胰腺肿瘤, 随访

Abstract:

Survival analysis of relevant factors for surgical treatment of pancreatic cancer HOU Bao-hua，OU Jin-rui. Department of Hepatobiliary-Panceatic Surgery, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou 510080, China Corresponding author: OU Jin-rui, E-mail：oujinrui@yahoo.com.cn Abstract Objectives To evaluate outcome of patients with pancreatic cancer under different surgical modalities,and to sum up the treatment experience for pancreatic cancer. Methods The follow-up data of 50 patients with pancreatic cancer between 1996 and 2006 were analyzed. SPSS 13.0 was performed to analyze the follow-up data. Results For 50 followed-up patients, 1, 3, 5 years cumulative survival rate is 63.0 %, 24.0%，12.0%, respectively. Operative mortality is 4% and 38.0% of patients have complication after operation. Cox regress indicates that surgery modus and staging are significantly risk factor for cumulative survival rate (p<0.05). Median of survival time and 3,5 years cumulative survival rate of patients performed by R0 resection are 30 months, 41.0%, 20.0%, respectively, which higher than R1 and R2 (p<0.05). Three, five-year cumulative survival rate of patients with stageⅠis 49.0% and 28.0%. Conclusion R0 resection is the only effective method to improve the rate of cumulative survival time.

Key words: pancreatic cancer, Follow-up study