中国实用外科杂志

中国实用外科杂志 ›› 2012, Vol. 32 ›› Issue (11): 887-888.

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弥漫性血管内凝血实质是内皮细胞重度炎性损伤

安友仲   

  1. 北京大学人民医院重症医学科，北京100044
  • 出版日期:2012-11-01 发布日期:2012-10-19

  • Online:2012-11-01 Published:2012-10-19

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摘要：

弥漫性血管内凝血（DIC）是一组综合征，而非某一特定病因所致的血液系统疾病。各种导致全身炎性反应的因素，损伤血管内皮细胞而引起凝血和（或）纤维蛋白溶解功能严重紊乱，是最终发展为DIC的共同病理生理机制。作为综合征，多样化的损伤因素使得DIC的诊断宜较为宽泛，而控制炎性反应对内皮细胞的损伤、针对不同基础病因的个别治疗是防治DIC的关键。

关键词: 弥漫性血管内凝血, 内皮细胞, 全身炎性反应综合征

Abstract:

Essence of disseminated intravascular coagulation：the severe endothelium inflammatory dysfunction        AN You-zhong. Department of Critical Care Medicine, Peking University People’s Hospital, Beijing 100044, China
Abstract    Disseminated intravascular coagulation (DIC) is an inflammatory syndrome but not a hematological disease by definite etiology. Any pathogen of SIRS damaging the endothelium may cause the dysfunction of coagulation and fibrinolysis, finally develop to DIC. As the syndrome, DIC may be diagnosed by several criterions of a standard group due to its multiple etiological factors. But the key therapy of DIC includes both protecting the endothelium from inflammatory damage and the pertinent treatment of different underlying diseases.

Key words: disseminated intravascular coagulation （DIC）, endothelium, systemic inflammatory response syndrome (SIRS)