中国实用外科杂志

中国实用外科杂志 ›› 2006, Vol. 26 ›› Issue (11): 1-865.

• 论蓍 •    

蛋白芯片法检测乳管液肿瘤标记物的临床研究

续哲莉，邢华   

  1. 吉林大学中日联谊医院乳腺甲状腺外科，吉林长春130033
  • 收稿日期:2006-06-09 修回日期:2006-07-31 出版日期:2006-10-31 发布日期:2006-10-31

Detection of tumor markers by approach of proteinum array in latex duct lavage.

Xu Zheli,Xing Hua.   

  1. Department of General Surgical,ChinaJapan Union Hospital,Jilin University,Changchun 130031,China
  • Received:2006-06-09 Revised:2006-07-31 Online:2006-10-31 Published:2006-10-31

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摘要：

目的:探讨乳腺疾病乳管液肿瘤标志物表达的意义。方法:2005年8～12月采用多肿瘤标志物蛋白芯片检测系统（C-12检测系统），联合测定22例乳腺癌和54例乳腺良性疾病病人的乳管液与血清中12项肿瘤标志物，并对阳性表达明显的CA19-9、CEA、CA242、铁蛋白、CA125、CA15-3等6项指标进行比较分析。结果:6种标志物在乳管液中的含量及表达的例数明显高于血清，且在乳腺癌组灵敏度明显提高。但乳腺癌与乳腺良性疾病病人比较，差异无显著性意义（P>0.05）。结论:采用C-12系统检测乳管液肿瘤标志物的灵敏度明显高于血清，但特异性较差。同时发现积乳症、乳管内乳头状瘤（病）与乳腺癌具有内在相关性。

关键词: 乳管液, 肿瘤标志物, 蛋白芯片

Abstract:

Objective:To study the value of tumor markers in breast duct juice for breast disease. Methods:By applying protein chip system for multitumor markers detection(c-12),simultaneous determination the tumor maker in breast duct juice and serum,the 22 patients were breast cancer and 54 patients had no cancer.The 6 index of obviously masculine expression (including CA19-9、CEA、CA242、ferritin、CA125、CA15-3) were analyzed and compared.The content of 6 index in breast duct juice was obviously high than in serum.In the breast cancer,the sensitivity was manifest raise. Results:But compare with the cancer and negative cancer,the discrepancy had no significance. Conclusion:By applying the C-12 system determination the tumor maker,the sensitivity of breast duct juice surpasses than in serum,but the specificity is not fine.And it can find out the internal dependability at the galactostasis,papillary epithelioma or papillomatosis and breast cancer.

Key words: breast duct juice, tumor markers, Protein chip