关键词: 分化型甲状腺癌, 基础研究, 热点

Abstract: Basic research hotspots and future directions of differentiated thyroid cancer   ZHANG Hao*，SUN Wei，TIAN Wen.  *Department of Thyroid Surgery，the First Hospital of China Medical University，Shenyang 110001，China
Corresponding authors：ZHANG Hao，E-mail：haozhang@cmu.edu.cn；TIAN Wen，E-mail：tianwen301_cta01@163.com
Abstract    The incidence of thyroid cancer increased most rapidly around world in recent years. Differentiated thyroid cancer (DTC) accounts for more than 90% of thyroid cancer. With the increasing incidence of DTC，the basic research of DTC has been paid more attention than before. At present，molecular diagnostic tools have high accuracy in the diagnosis of benign and malignant nodules，but the high price limits its clinical application. The preoperative diagnosis of thyroid follicular cancer and noninvasive follicular thyroid neoplasm with papillary-like nuclear features is still lack of effective markers and diagnostic models. In terms of prognostic markers，although the prognostic value of BRAF and TERT mutations for PTC has been well elucidated，there is still a lack of accurate prognostic model combined with multiple genes. Besides TG and TGAb，miRNAs may provide new ideas for follow-up monitoring of DTC. In the aspect of targeted therapy，tyrosine kinase inhibitors and neoadjuvant therapy for DTC specific gene mutations and pathways have become the focus of attention.

Key words: differentiated thyroid cancer, basic research, hotspot