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上海市普通外科住院病人静脉血栓栓塞症诊治现状调查分析

楼文晖,程    健,李聚欣秦新裕代表上海市普通外科临床质量控制中心研究者团队   

  1. 复旦大学附属中山医院普外科,上海2000032
  • 出版日期:2020-05-01 发布日期:2020-05-15

  • Online:2020-05-01 Published:2020-05-15

摘要: 目的    调研了解上海市二级甲等及以上医院普痛外科有关静脉血栓栓塞症(VTE)院内防控体系建立情况、医生相关知识掌握,住院病人发病情况。方法    2019年9月1—12日以上海市普通外科临床质量控制中心为平台,设计问卷并以质量控制中心官方邮件及微信平台共同推送二维码形式对上海市二级甲等及以上医院普通外科进行电子问卷调查。问卷内容设计严格按照国内外普通外科领域VTE防治指南为标准。结果    共69家医院普通外科参与调研,回收有效问卷112份,肺动脉栓塞(PE)确诊例数占住院手术例数的0.06%(5/7843),深静脉血栓形成(DVT)确诊例数占1.02%(80/7843)。上海市二级及以上医院已有88.39%(99/112)的科室建立VTE防控体系;84.82%(95/112)的科室有VTE和PE的联合会诊团队;96.43%(108/112)的科室入院时为病人做VTE风险评估,74.11%(83/112)的科室在病人手术后评估VTE风险,38.39%(43/112)的科室出院前为病人评估VTE风险。有53.57%(60/112)的科室为VTE高风险病人进行术前抗凝,至术前12 h停药。34.61%(18/52)的科室因顾虑出血,以及23.07%(12/52)的科室认为外科手术前无须抗凝,而术前不予抗凝治疗。在术后抗凝治疗中,对良性疾病病人,43.75%(49/112)的科室对予术后抗凝3~5 d,23.21%(26/112)予抗凝至出院前,4.46%(5/112)予抗凝至可自由行走,2.68%(3/112)予抗凝至术后28 d,25.89%(29/112)术后未予常规预防性抗凝;对于恶性疾病病人,47.32%(53/112)科室予抗凝至出院前,23.21%(26/112)予术后抗凝3~5 d,仅有8.04%(9/112)根据规范推荐抗凝至术后28 d。院内预防中有96.43%(108/112)的科室选择低分子肝素;院外预防中有43.75%(49/112)的科室使用阿司匹林,16.07%(18/112)使用低分子肝素,24.11%(27/112)使用新型口服抗凝药,15.18%(17/112)使用华法林。结论    与2年前对比,上海市普通外科VTE防治的理念和实践有了很大的进步,但对照先进国家的防治实践,存在较大差距,尤其在为病人选择正确用药及恶性肿瘤等VTE高危病人的预防上仍有改善空间。

关键词: 静脉血栓栓塞症, 普通外科, 横断面调查

Abstract: Survey of clinical diagnosis and treatment of venous thromboembolism in general surgery inpatients in Shanghai        LOU Wen-hui, CHENG Jian, LI Ju-xin, et al. On behalf the research team of Clinical Quality Control Center of General Surgery in Shanghai. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Corresponding author: QIN Xin-yu, E-mail: qin.xinyu@zs-hospital.sh.cn
Abstract    Objective    To investigate 3 priority issues of venous thromboembolism(VTE) in Shanghai including the establishment of prevention and control system of venous thromboembolism (VTE) in Department of General Surgery, doctors understanding of VTE knowledge and the incidence of VTE in the investigated department. Methods    From September 1 to 12, 2019, the questionnaire was designed strictly according to the international and Chinese guidelines of prophylaxis and treatment of VTE in general surgery, which formed as QR code, sent by the Shanghai General Surgery Clinical Quality Control Center with official email and social media: We Chat. Results    Sixty-nine hospitals were participated in the survey and a total of 112 valid questionnaires were retrieved. The incidence of confirmed pulmonary embolism (PE) cases were reported for 0.06% (5/7843), and the incidence of confirmed deep vein thrombosis (DVT) was 1.02% (80/7843). By September 12, 2019, 88.39% (99/112) of departments of third and second grade hospitals in Shanghai had established VTE prevention and control system; 84.82% (95/112) of departments had joint consultation teams of VTE and PE; 96.43% (108/112) departments stared to assess VTE risk for patients from admitting to hospital, 74.11% (83/112) of departments evaluated the VTE risk right after surgery and 38.39% (43/112) of departments evaluated the risk of VTE for patients before discharge. Before operation, 53.57% (60/112) of departments gave anticoagulation therapy for the patients with high risk of VTE, and stopped at 12 hours before operation; And 34.61% (18/52) of departments were concerned about bleeding, while 23.07% (12/52) didn’t give anticoagulation therapy holding the view that anticoagulation was not needed before surgery. In postoperative anticoagulation therapy, for the patients with benign diseases, 43.75% (49/112) of departments maintained for 3 to 5 days, 23.21% (26/112) continued until discharge, 4.46% (5/112) until free walking, 2.68% (3/112) until 28 days after operation, however 25.89% (29/112) of departments didn’t give anticoagulation therapy after operation; For the patients with malignant diseases, 47.32% (53/112) of departments gave anticoagulation therapy before discharge, 23.21% (26/112) maintained anticoagulation therapy until 3 to 5 days after operation, and only 8.04% (9/112) maintained anticoagulation therapy to 28 days after operation according to recommendation. When the situation comes to the prophylaxis of anticoagulation therapy, 96.43% (108/112) of departments chose low molecular weight heparin as the inpatient surgical methods. While for the outpatient surgical patients, 43.75% (49/112) of departments chose aspirin, 16.07% (18/112) chose LMWH, 24.11% (27/112) chose novel oral anticoagulants, and 15.18% (17/112) chose warfarin. Conclusion    Great progress has been made in doctors understanding and medical practice of prevention and control of VTE in Department of General Surgery in Shanghai compared with two years ago. However, there is still a medical practicing gap that prophylaxis and treatment of VTE between Shanghai and international guideline, especially the correct way to performing prophylaxis of anticoagulantion therapy (anticoagulants choosing and timing), and the prevention of patients with malignant diseases and high risk of VTE.

Key words: venous thromboembolism, general surgery, cross sectional investigation