关键词: 粪菌移植, 慢传输型便秘, 排便次数, Wexner便秘评分

Abstract:

Fecal microbiota transplantation for treatment of slow transit constipation: A clinical study of 20 patients                   TIAN Hong-liang，DING Chao，GONG Jian-feng，et al. Department of General Surgery，Jinling Hospital，Medical School of Nanjing University，Nanjing 210002， China
Corresponding author：LI Ning，E-mail: liningrigsnju@163.com
Abstract    Objective    To examine the safety and efficacy of fecal microbiota transplantation (FMT) for slow transit constipation (STC). Methods    Twenty patients with STC were enrolled in the prospective open-label study. All the patients were performed FMT. Autonomous defecation frequency，Wexner constipation scale, bowel movement and related adverse reaction per week around FMT were evaluated at each study visit. All the patients were followed up for 8 weeks. Results    Compared with pre-FMT treatment，the patient’s stool frequency increased significantly ［(1.5 ± 1.3) times/week vs. (4.5±1.5) times/week］ after eight weeks of treatment. Meanwhile，Wexner constipation scores demonstrated a significant reduction ［(15.7 ± 3.5) vs. (7.5 ± 1.6)］ and GIQLI score increased remarkably［(84.6 ± 12.5) vs. (116.6 ± 11.5)］, which has significant difference statistically (P<0.05). There were 12 patients obtained clinical improvement and seven patients obtained clinical remission till to 8 weeks. FMT efficacy was stable and no serious adverse event occurred during the whole follow-up. Conclusion    FMT is safe and effective for treating slow transit constipation and the short-term treatment effect is good.

Key words: fecal microbiota transplantation, slow transit constipation, stool frequency, Wexner constipation scores