关键词: NCCN, Ⅳ期、转移复发乳腺癌, 局部手术, 综合治疗

Abstract:

2015 NCCN Clinical Practice Guidelines in Oncology: Interpretation of stage IV metastatic or recurrent breast cancer        ZHENG, Xin-yu. Department of Breast Surgery,  the First Affiliated Hospital, China Medical University, Shenyang 110001, China
Abstract    2015 NCCN Guidelines Insights highlight the important changes specific to the management of metastatic breast cancer in the Version 2 2015 of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer. The highlights include the issue of retesting of biomarkers (estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2) on recurrent disease. The consensus of the preferred surgical approach for most women with a local recurrence following breast-conserving therapy and sentinel node biopsy is mastectomy and a level Ⅰ/Ⅱ axillary dissection. The use of the minimally toxic endocrine therapies is preferred to the use of cytotoxic therapy whenever reasonable. The endocrine therapy could be combined with an mTOR inhibitor as a subsequent therapeutic option by considering the addition of everolimus to exemestane in women who fulfill the entry criteria of the RCT. The panel emphasized the importance of individualizing treatment strategies in patients with a recurrence of disease because of their complicated and varied treatment background.

Key words: National Comprehensive Cancer Network, stage Ⅳ metastatic or recurrent breast cancer；locoregional surgery；systemic therapy