中国实用外科杂志

中国实用外科杂志

• 专题笔谈 • 上一篇    下一篇

下肢动脉硬化闭塞症治疗中载药器械应用

郭    伟，卫    任   

  1. 中国人民解放军总医院血管外科，北京100853
  • 出版日期:2016-12-01 发布日期:2016-12-01

  • Online:2016-12-01 Published:2016-12-01

摘要：

以药物洗脱支架和药物涂层球囊为代表的载药器械的应用，为下肢动脉硬化闭塞症的治疗提供了新的策略。围绕二者的高证据级别的临床试验也广泛开展。在对股腘动脉病变的治疗中，负载紫杉醇的药物洗脱支架及药物涂层球囊均表现出较好的一期通畅率，但在改善症状方面结果并不一致。在治疗膝下动脉病变中，药物洗脱支架的优势已基本确立，而药物涂层球囊的潜在价值尚待更多临床试验予以证实。

关键词: 药物洗脱支架, 药物涂层球囊, 动脉硬化闭塞症, 股腘动脉, 膝下动脉

Abstract:

Application of drug loaded instruments in treating arteriosclerosis obliterans        GUO Wei, WEI Ren. Department of Vascular Surgery, General Hospital of PLA, Beijing 100853, China
Corresponding author: GUO Wei, E-mail: pla301dml@vip.sina.com
Abstract    Drug loaded instruments, represented by drug eluting stent (DES) and drug coated balloon (DCB), have provided new ways for treating arteriosclerosis obliterans(ASO). High level clinical trials related have been extensive. DES and DCB loaded with paclitaxel have presented with better primary patency and uncertain symptoms improvement in treating femoral-popliteal artery lesions. For treating infra-popliteal artery lesions, the predominance of DES has been basically established, while the potential value of DCB still need to be tested by more clinical trials.

Key words: drug eluting stent, drug coated balloon, arteriosclerosis obliterans, femoral-popliteal artery, infra-popliteal artery