关键词: 胃肠间质瘤, 美国国立综合癌症网络

Abstract:

Updates and interpretations of the NCCN Clinical Practice Guidelines (2016 second version) on gastrointestinal stromal tumor        WANG Ming, CAO Hui. Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Corresponding author: CAO Hui, E-mail: caohuishcn@hotmail.com
Abstract    The diagnosis and treatment of gastrointestinal stromal tumor (GIST) is getting more and more standardized. In the last decade, due to the revelation of the molecular mechanism of its tumorigenesis, as well as the effectiveness of tyrosine kinase inhibitors, GIST has become well known as one of the most classical model of target therapy on solid tumor in the precision medicine era. The National Comprehensive Cancer Network (NCCN) issued the latest version of clinical practice guideline on GIST in Feb. 2016. The updated guideline emphasized the importance of the management of wild-type GIST, also updated the surveillance strategy of very small gastric GIST (<2cm), and the predictor of GIST biological behavior. This paper provides interpretations of these updates, aiming to improve the clinical practice of GIST.

Key words: gastrointestinal stromal tumor, National Comprehensive Cancer Network