中国实用外科杂志

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甲状腺微小乳头状癌过度治疗与不足

朱精强雷建勇   

  1. 四川大学华西医院甲状(旁)腺疾病诊治中心,四川成都 610041
  • 出版日期:2016-05-01 发布日期:2016-04-28

  • Online:2016-05-01 Published:2016-04-28

摘要:

近年来,关于甲状腺微小乳头状癌(PTMC)的诊治争议越来越大,对其治疗不足和过度治疗在临床中同时存在。治疗不足包括:应手术者未行手术;首选消融治疗;违背“两个至少”的原则;对侧侧区有淋巴结转移病例仅行患侧腺叶+峡部切除术及患侧中央区+颈侧区淋巴结清扫;合并对侧叶结节的PTMC仅行腺叶切除;术后不评估、不随访、不行恰当的促甲状腺激素(TSH)抑制治疗。而过度治疗则包括:对肿瘤直径<5 mm,对侧腺叶无结节、无颈淋巴结转移、甲状腺外浸润等,以及其他甲状腺癌高危因素的病例行全甲状腺切除术+单或双侧中央区淋巴结清扫;因良性病变已行腺叶+峡部切除术,术后病理检查发现PTMC(意外癌),无中央区淋巴结转移依据而再行中央区淋巴结清扫;对肿瘤直径<5 mm的PTMC病人于妊娠早、晚期手术;行过度的TSH抑制治疗及随访周期<3个月等。鉴于此,临床应正确认识PTMC,依据现有科学水平进行正确评估,依据手术的安全性、病人意愿及医疗资源等因素综合判断,制定合理的诊疗方案。

关键词: 甲状腺微小乳头状癌, 过度治疗, 治疗不足

Abstract:

Over-treatment and under-treatment of papillary thyroid microcarcinoma        ZHU Jing-qiang,LEI Jian-yong. Thyroid and Parathyroid Surgery Center,West China Hospital of Sichuan University,Chengdu 610041,China
Corresponding author:ZHU Jing-qiang,E-mail:zjq-wkys@163.com
Abstract    In recent years,the treatment for the papillary thyroid microcarcinom(PTMC)is controversial, which includes over-treatment and under-treatment in the clinical. The following protocols should be considered as “under-treatment”:ablation therapy is the first choice;against to the principle of “two at least”;for patients with proved contralateral lymph node metastasis only performed ipsilateral lobectomy and central lymph node dissection and lateral lymph node dissection;for patients with node in the contralateral lobe only performed ipsilateral lobectomy;cases should accept surgery therapy but failed;inappropriate TSH suppression therapy without evaluation and follow-up after surgery. The following protocols should be considered as “over-treatment”:PTMC with diameter less than 5 mm,without lymph node metastasis and no risk factors of capsular invasion,but accepting total thyroidectomy or unilateral/bilateral central lymph node dissection;cases have accepted lobectomy and the postoperative histological examination indicated the “accidental carcinoma”,but been advised to accept the central lymph node dissection without evidence of lymph node metastasis;PTMC patients with diameter less than 5 mm accepted surgery in the early or late pregnancy period;cases accepted over TSH suppression therapy and the follow-up less than 3 months. So the surgeon should have a correct understanding of PTMC with correct assessment,safety consideration of surgery,patients’ will and medical resources,and then make the reasonable diagnosis and treatment protocols.

Key words: papillary thyroid microcarcinoma, over-treatment, under-treatment