中国实用外科杂志

中国实用外科杂志

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简易乳腺磁共振序列筛选乳腺癌临床可行性研究

武    靖a，郭嘉嘉b，王    殊b，李安琪a，康    钰a，洪    楠a，王    屹a   

  1. 北京大学人民医院  a放射科  b 乳腺中心，北京 100044
  • 出版日期:2016-04-01 发布日期:2016-03-29

  • Online:2016-04-01 Published:2016-03-29

摘要：

目的    探讨乳腺磁共振简易序列（BMRI-AP）筛选乳腺癌的临床可行性。方法    收集2010年5月至2014年12月北京大学人民医院214例经钼靶或超声怀疑乳腺单发结节的女性病人行BMRI检查。以术后病理学检查为金标准，比较BMRI-AP和全扫描序列（BMRI-FDP）筛选乳腺癌的敏感度、特异度、阳性预测值及阴性预测值。结果    BMRI-AP及BMRI-FDP检查及阅读时间分别为5 min，45s及25min，1200s，均检出全部119例乳腺癌。BMRI-AP诊断乳腺癌敏感度（97.5%）及阴性预测值（95.9%）高于BMRI-FDPF （95.8%和94.0%），但差异无统计学意义（P=0.72和P=0.72）。尽管BMRI-AP诊断乳腺癌特异度（73.7%）和阳性预测值（82.3%）低于BMRI-FDP（82.1%和87.0%），但同样差异无统计学意义（P=0.22和P=0.32）。结论    BMRI-AP与BMRI-FDP相比，诊断乳腺癌的敏感度及特异度相似，但检查和阅片时间却显著缩短。BMRI-AP是临床可行筛选乳腺癌的影像学方法。

关键词: 筛查, 乳腺癌, 磁共振, 磁共振简易序列

Abstract:

Breast magnetic resonance imaging with abbreviated protocol in detection and diagnosis of breast cancer                    WU Jing*，GUO Jia-jia，WANG Shu，et al. *Department of Radiology，Peking University People’s Hospital, Beijing 100044, China
Corresponding author: WANG Yi, E-mail: wangyi@pkuph.edu.cn
Abstract    Objective    To investigate the feasibility of breast magnetic resonance imaging (BMRI) with an abbreviated protocol (BMRI-AP) in detection and diagnosis of breast carcinoma. Methods    A total of 214 patients with single lesion suspected by digital mammograms or ultrasounds admitted from May 2010 to December 2014 in Peking University People’s Hospital were performed BMRI. All patients underwent BMRI-AP and full diagnostic protocol BMRI (BMRI-FDP). Two radiologists detected and diagnosed breast carcinomas based on criteria of Breast Imaging Reporting and Data System (BI-RADS) . Sensitivity，specificity，positive predictive value (PPV) and negative predictive value (NPV) of BMRI-AP and BMRI-FDP were analyzed and compared. Results    Both BMRI-AP and BMRI-FDP could detect 119 breast carcinomas that were confirmed by pathological analyses. The imaging acquisition and interpretation time of BMRI-AP and BMRI-FDP were 5min, 45s and 25min, 1200s, respectively. The ability of BMRI-AP and BMRI-FDP in determination of breast carcinoma were shown as sensitivity of 97.5% and 95.8%，specificity of 73.7% and 82.1%, PPV of 82.1% and 87.0%, and NPV of 95.9% and 94.0%, respectively. But there was no statistical significance (P=0.72, P=0.22, P=0.32, P=0.72). Conclusion    BMRI-AP with shorter acquisition time and interpretation time has similar sensitivity and specificity in detection and diagnosis of breast cancer compared with BMRI-FDP. BMRI-AP is demonstrated as one of efficient imaging tool in screening breast carcinoma. 

Key words: breast carcinoma, breast cancer, magnetic resonance imaging（MRI）, magnetic resonance imaging with abbreviated protocol