关键词: 胃癌, 腹腔种植转移, 腹腔热灌注化疗, 肿瘤细胞减灭术

Abstract:

Hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis of gastric cancer            WU Xiao-jiang, JIA Yong-ning, JI Jia-fu. Department of Gastrointestinal Surgery, Peking University School of Oncology, Beijing Cancer Hospital & Institute; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China
Corresponding author: JI Jia-fu, E-mail：jiafuji@hotmail.com
Abstract    The peritoneal carcinomatosis is the main cause of death for gastric cancer. Once diagnosed, the prognosis is poor extremely. While simple peritoneal carcinomatosis has been considered as localized disease gradually, and more aggressive methods could be adopted including hyperthermic intraperitoneal chemotherapy (HIPEC) and peritoneal resection. Combination of surgery and HIPEC could significantly decrease the recurrence rate, and the combination of CRS and HIPEC could also enhance the therapeutic effect of gastric cancer patients with obvious peritoneal dissemination. Careful selection of the potential beneficiary is the key for better survival. But up to now a standard protocol is demanded highly, and more prospective clinical trials are needed to provide enough evidence for the protocol conformation.

Key words: gastric cancer, peritoneal carcinomatosis, hyperthermic intraperitoneal chemotherapy, cytoreductive surgery